Last edited by Mezizragore
Saturday, August 8, 2020 | History

5 edition of Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy found in the catalog.

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy

by Toshiwo Andoh

  • 97 Want to read
  • 27 Currently reading

Published by CRC Press .
Written in English

    Subjects:
  • Life Sciences - Biology - Molecular Biology,
  • Pharmacology,
  • Dna (Deoxyribonucleic Acid),
  • Chemotherapy,
  • Medical / Nursing,
  • Oncology,
  • Science/Mathematics,
  • Inhibitors,
  • Infectious & contagious diseases,
  • Molecular biology,
  • Specific disorders & therapies,
  • Cancer,
  • Congresses,
  • DNA topoisomerase I,
  • DNA topoisomerase II

  • Edition Notes

    ContributionsHideo Ikeda (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages400
    ID Numbers
    Open LibraryOL8260524M
    ISBN 100849349702
    ISBN 109780849349706

    In molecular biology Type I topoisomerases are enzymes that cut one of the two strands of double-stranded DNA, relax the strand, and reanneal the strand. They are further subdivided into two structurally and mechanistically distinct topoisomerases: type IA and type ro: IPR DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA. In addition, these enzymes fine-tune the steady-state level of DNA supercoiling both to facilitate protein interactions with the DNA and to prevent excessive .

    It is interesting to note that type IA topoisomerases form a covalent intermediate with the 5′ end of DNA, while the IB topoisomerases form a covalent intermediate with the 3′ end of DNA. Recently, a type IC topoisomerase has been identified, called topo V. While it is structurally unique from type IA and IB topoisomerases, it shares a.   Doxorubicin is among the most effective and widely used anticancer drugs in the clinic. However, cardiotoxicity is one of the life-threatening side effects of doxorubicin-based therapy. Dexrazoxane (Zinecard, also known as ICRF) has been used in the clinic as a cardioprotectant against doxorubicin cardiotoxicity. The molecular basis for doxorubicin Cited by:

      This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular : Springer US.   New molecular biologist perspective and insight: DNA topoisomerases production by recombinant DNA technology for medical laboratory application and pharmaceutical industry DNA topoisomerases are essential enzymes that control the topological state of DNA replication during mitosis.


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Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy by Toshiwo Andoh Download PDF EPUB FB2

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of : Toshiwo Andoh.

Molecular biology of DNA topoisomerases and its application to chemotherapy: proceedings of the International Symposium on DNA Topoisomerases in Chemotherapy, Nagoya, Japan, November(ISTOP ).

Such mechanistic studies have already played an important role in the development and clinical application of antimicrobial and chemotherapeutic agents.

The two volumes of DNA Topoisomerase Protocols are designed to help new and established researchers investigate all aspects of DNA topology and the function of these : Hardcover.

Howard M, Neece S, Matson S, Kreuzer K () Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase. (in press) Google Scholar Huang W () Multiple DNA gyrase-like genes in eubacteria. In: Andoh T, Ikeda H, Oguro M (eds) Molecular biology of DNA topoisomerases and its application to by: the chemical biology of the topoisomcrase inhibitors used cancer chemotherapy and the implication of in recombinations and DNA third Section the current use of the various topoisomcrase inhibitors in cancer chemotherapy.

And the last section describing the DNA repair pathways for topoisomerase-induced DNA damage. This book is inte-File Size: 3MB. The enzymes that regulate the topological state of the genetic material are known as topoisomerases [3, 4, 9–14, 22–25].

Topoisomerases are required for the survival of all organisms and alter DNA topology by generating transient. He has authored over publications and holds over 20 patents for inhibitors of DNA topoisomerases, Tyrosyl-DNA phosphodiesterase, checkpoint inhibitors, and HIV-1 integrase inhibitors.

Two of his patented novel topoisomerase I inhibitors are in clinical development. Despite its importance in cancer chemotherapy, evidence suggests that topoisomerase II-mediated DNA cleavage triggers chromosomal translocations that lead to specific types of leukemia (see Fig.

5) [10, 12, 15, 16, 41]. To this point, some regimens that include topoisomerase II-targeted drugs, especially etoposide, are associated with the Cited by: Department of Molecular and Structural Biology University of Aarhus Arhus C, Denmark. The double-helical nature of DNA and the anchoring of DNA to nuclear structures result in a number of topological problems during replication and transcription, mainly due to DNA-tracking polymerases and heli- Size: 1MB.

DNA topoisomerases are marvelous molecular machines that manage the topo-logical state of the DNA in the cell. These enzymes accomplish this feat by either passing one strand of the DNA through a break in the opposing strand (type IFile Size: 1MB.

The following section reviews the chemical biology of the topoisomerase inhibitors used in cancer chemotherapy and the implication of topoisomerases in generating recombinations and DNA damage. The third section summarizes the current use of the various topoisomerase inhibitors in cancer chemotherapy.

Despite its importance in cancer chemotherapy, evidence suggests that topoisomerase II‐mediated DNA cleavage triggers chromosomal translocations that lead to specific types of leukemia (see Fig.

5) [10, 12, 15, 16, 41]. To this point, some regimens that include topoisomerase II‐targeted drugs, especially etoposide, are associated with the Cited by: DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.

Experts on DNA repair proteins from all areas of cancer biology. DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.

Topotecan (TPT) is in clinical use as an antitumor agent. It acts by binding to the covalent complex formed between nicked DNA and topoisomerase I. DNA topoisomerases bond covalently to the DNA phosphate as they break the phosphodiester linkage between neighboring nucleotides, storing the energy in that bond to use in the process of resealing the bond.

They are thus in effect reversible nucleases that break and reseal the DNA molecule rapidly and efficiently. In book: Molecular Biology of DNA Topoisomerases and its application to Chemotherapy, Chapter: Phenotypic properties of Chinese hamster lung cells resistant to DNA topoisomerase II.

Dioxiribose nucleic acid molecules, or DNA, are absolutely essential to the function of all life forms on contain the massive amount of information held by their atomic structures, cellular molecules of DNA are supercoiled to conserve space.

This allows a collection of structures that would be two meters long if stretched end to end to exist neatly. DNA topoisomerases are enzymes that control the topological state of DNA in all cells; they have central roles in DNA replication and transcription.

They are classified into two types, I and II, depending on whether they catalyze reactions involving the. Topoisomerases (or DNA topoisomerases) are enzymes that participate in the overwinding or underwinding of winding problem of DNA arises due to the intertwined nature of its double-helical structure.

During DNA replication and transcription, DNA becomes overwound ahead of a replication left unabated, this torsion would eventually stop the ability of DNA. This GRC will be held in conjunction with the "DNA Topoisomerases in Biology and Medicine (GRS)".

Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.1. Author(s): Andoh,Toshiwo; Ikeda,Hideo,Ph.

D.; Oguro,Masao; International Symposium on DNA Topoisomerases in Chemotherapy,( Nagoya-shi, Japan) Title(s): Molecular biology of DNA topoisomerases and its application to chemotherapy: proceedings of the International Symposium on DNA Topoisomerases in Chemotherapy, Nagoya, Japan.

Type II topoisomerases cut both strands of the DNA helix simultaneously in order to manage DNA tangles and use the hydrolysis of ATP, unlike Type I this process, these enzymes change the linking number of circular DNA by ±: BRENDA entry.